It is used in the post-gastrectomy period and in cases of functional disorders of the gastrointestinal tract.
Each enteric-coated tablet contains:
Pancreatin USP, providing:
Amylase activity โ 15,000 USP units
Lipase activity โ 4,000 USP units
Protease activity โ 15,000 USP units
Sodium tauroglycocholate BPC 54 โ 65 mg
Sugar coating containing essential carminative oils
Digestive disorders are most often caused by improper diet and overeating. Discomfort, flatulence, and abdominal colic may occur when the bodyโs own pancreatic enzymes cannot handle large amounts of food.
In such cases, the enzymes in Lipoferโข Forte naturally improve digestion and reduce undigested food, where fermentation and putrefaction processes occur.
Lipofer Forte enhances digestion due to its balanced formula:
Amylase helps digest starch
Lipase aids in fat digestion
Protease is necessary for protein digestion
Small molecules formed by lipase action on fats are absorbed only if they are water-soluble. While glycerol dissolves in water, fats and fatty acids do not. This is resolved by bile saltsโspecifically sodium tauroglycocholate in Lipofer Forte.
Bile salts:
Emulsify fats and improve enzyme activity
Enhance lipid digestion
Promote absorption of iron, calcium, and fat-soluble vitamins (A, D, E, K)
Increase intestinal motility, producing a mild laxative effect
Thus, in addition to aiding digestion of carbohydrates, fats, and proteins, Lipofer Forte improves fat absorption and has a mild laxative effect.
Pharmacokinetic data for oral enzymes in humans are not well studied. Some enzymes may be absorbed in the small intestine via entero-pancreatic circulation.
Pancreatic enzyme insufficiency (chronic pancreatitis, cystic fibrosis, after pancreatectomy, pancreatic cancer)
Chronic inflammatory and degenerative diseases of the intestines, stomach, liver, and gallbladder, especially after resection or radiation
Conditions associated with flatulence, diarrhea, and digestive disorders
Post-gastrectomy condition
Functional GI disorders (intestinal infections, irritable bowel syndrome)
Relief of symptoms such as bloating, dyspepsia, abdominal distension, diarrhea
Before ultrasound or radiological examination of the digestive tract
Dosage is individualized based on steatorrhea and dietary fat content.
Start with the lowest dose and gradually increase until adequate control is achieved.
Tablets should be swallowed whole (do not chew) with sufficient water.
Infants (under 12 months):
2,000โ4,000 USP lipase units per 120 ml feeding
Children (over 12 months) and adults:
Under 4 years: 1,000 USP lipase units/kg per meal (max 2,500 units/kg)
Over 4 years: 400 USP lipase units/kg per meal (max 2,500 units/kg)
If higher doses are needed, further investigation is required.
Maximum: 10,000 lipase units/kg/day.
Take during meals or snacks.
Avoid foods with pH above 7.3 when administering (may damage coating).
Do not keep tablets in the mouth (may cause mucosal irritation or ulcers).
Hypersensitivity to components
Hypersensitivity to porcine-derived products
Most common: gastrointestinal disturbances
Nausea, vomiting
Epigastric discomfort
Flatulence
Diarrhea or constipation
Less common:
Itching, urticaria, rash
High doses (long-term):
Hyperuricemia, hyperuricosuria
Fibrosing colonopathy (especially in cystic fibrosis patients)
Folic acid monitoring may be required.
Use only under medical supervision when benefits outweigh risks.
No known teratogenic effects.
Very high doses may cause hyperuricemia and hyperuricosuria.
Treatment is symptomatic.
Aluminum-containing antacids may reduce effectiveness
Calcium carbonate or magnesium hydroxide antacids should not be used together (may impair fat absorption)
Store below 25ยฐC.
Protect from light and moisture.
Keep out of reach of children.
