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Etoricoxib
Non-steroidal anti-inflammatory drug (NSAID).
Film-coated tablets:
60 mg – Green color.
90 mg – White color.
120 mg – Light green color.
Etoricoxib is a selective inhibitor of cyclooxygenase-2 (COX-2). At therapeutic concentrations, it blocks the formation of prostaglandins and is characterized by anti-inflammatory, analgesic, and antipyretic action.
The selective inhibition of COX-2 by Etoricoxib is accompanied by a reduction in pronounced clinical symptoms related to inflammatory processes, without affecting platelets and the gastrointestinal tract mucosa.
Etoricoxib has a dose-dependent effect on COX-2 inhibition, without affecting COX-1 when used at doses up to $150 \text{ mg}$ per day. The preparation does not affect the production of prostaglandins in the gastric mucosa and bleeding time. Conducted studies did not show a reduction in arachidonic acid levels or collagen-induced platelet aggregation.
Hypersensitivity to any component of the preparation.
Complete or incomplete combination with bronchial asthma, recurrent nasal polyposis.
Intolerance to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (including in history).
Erosive-ulcerative damage to the stomach and duodenum, active gastrointestinal bleeding.
Cerebrovascular or other types of bleeding.
Inflammatory bowel diseases (Crohn's disease, non-specific ulcerative colitis) in the exacerbation phase.
Hemophilia and other types of blood clotting disorders.
Severe heart failure (NYHA II–IV).
Severe hepatic failure (more than 9 points according to the CHILD-PUGH scale) or active liver disease.
Severe renal failure (creatinine clearance $<30 \text{ mL/min}$), progressive kidney disease.
Confirmed hyperkalemia.
Post-aortocoronary bypass grafting period.
Peripheral arterial disease, cerebrovascular disease.
Clinically expressed ischemic heart disease.
Persistent arterial hypertension, uncontrolled arterial hypertension $>140/90 \text{ mmHg}$.
Pregnancy, lactation; children under 16 years of age.
Note: The preparation may negatively affect female fertility and is therefore not recommended for women planning pregnancy.
