Alponal is used for the treatment of most existing helminthiases.
Each coated tablet contains:
Albendazole — 200 mg.
Excipients: lactose monohydrate, magnesium carbonate, sodium croscarmellose, sodium bicarbonate, sodium lauryl sulfate, sodium saccharin, povidone K90, polysorbate 80, orange flavor, sodium starch glycolate, purified talc, magnesium stearate, hypromellose 2910, titanium dioxide (E171), polyethylene glycol 6000, simethicone emulsion.
Alponal is used for the treatment of most existing helminthiases, including:
Nematodoses (roundworms) – enterobiasis (caused by Enterobius vermicularis), ascariasis (caused by Ascaris lumbricoides), ancylostomiasis (caused by Ancylostoma duodenale and Necator americanus), strongyloidiasis (caused by Strongyloides stercoralis), trichocephalosis (caused by Trichuris trichiura);
Cestodoses (tapeworm infections) – neurocysticercosis (caused by Taenia solium), and liver, lung, and peritoneal echinococcosis (caused by Echinococcus granulosus) (used in cystic forms of helminthiasis);
As an adjunct in surgical treatment of echinococcal cysts during preoperative and postoperative periods;
Mixed infections caused by several helminths.
The drug is taken orally with or after food. No special preparation or diet is required. The dosage is determined individually depending on the type of infestation and the patient’s body weight.
For treatment of nematodoses in adults and children over 2 years old: 2 tablets (400 mg) once; for children under 2 years old: 1 tablet (200 mg) once.
To prevent reinfection, repeat the treatment course after 3 weeks with the same dose.
For neurocysticercosis and echinococcosis:
Patients weighing 60 kg or more: 2 tablets (400 mg) albendazole twice daily;
Patients weighing less than 60 kg: 15 mg/kg/day divided into two doses.
Maximum daily dose is 800 mg (4 tablets).
Duration of treatment: 8–30 days for neurocysticercosis; three 28-day courses for echinococcosis with 14-day intervals between courses.
In inoperable echinococcal cysts, up to 5 treatment courses may be given.
Gastrointestinal: nausea, vomiting, abdominal pain, anorexia, diarrhea, mild to moderate increase in liver transaminases;
Hematologic: leukopenia, granulocytopenia, agranulocytosis, thrombocytopenia, pancytopenia;
Nervous system: headache, dizziness, meningeal symptoms;
Dermatologic: rash, itching, reversible alopecia;
Others (rare): sore throat, fever, acute renal failure, increased blood pressure, weakness, fatigue.
Hypersensitivity to albendazole or any component of the drug, or to other benzimidazole derivatives;
Retinal diseases;
Pregnancy and lactation.
Use during pregnancy is contraindicated. Women of reproductive age should undergo a pregnancy test before starting treatment to exclude pregnancy. It is preferable to start treatment during the first 7 days of the menstrual cycle. During treatment and for 1 month after its completion, contraception is recommended. Use during breastfeeding is not advised.
Alponal should be used with caution in patients with hematopoietic, liver, or kidney disorders. Peripheral blood counts and liver function tests should be monitored before and during treatment. Therapy should be temporarily discontinued if leukopenia occurs and may be resumed if leukopenia is mild and non-progressive.
In neurocysticercosis, albendazole is administered together with glucocorticosteroids and anticonvulsants to prevent hypertensive crises during the first week of anti-cyst therapy.
Simultaneous treatment of all family members is recommended during albendazole therapy. Strict personal hygiene rules must be observed.
The drug does not affect the ability to drive vehicles or operate machinery.
Store at temperatures not exceeding 30ºC in a place inaccessible to children.
