Puroxan 400 mg tablets help relieve symptoms of bronchial asthma, difficulty breathing, and dry cough, providing effective relief.
DOXOFYLLINE
Doxofylline
Treatment of bronchial asthma
Bronchodilator
Phosphodiesterase inhibitor
Tablets (blister pack, 10 or 20 tablets)
Each tablet contains:
Doxofylline 400 mg
Excipients: colloidal silicon dioxide, wheat starch, mannitol, povidone, microcrystalline cellulose, talc, magnesium stearate
Syrup 2% (bottle, 100 ml)
Doxofylline 2 g
Excipients: sucrose, sodium saccharin, ammonium glycyrrhizinate, sodium methyl paraben, sodium propyl paraben, alpine cream base, peppermint flavor powder, purified water
Doxofylline is indicated for:
Patients with bronchial asthma
Patients with chronic obstructive pulmonary disease (COPD)
Tablets
Adults: 1 tablet (400 mg) twice daily
Dose may be increased up to 1200 mg per day as prescribed by a physician
Elderly patients with cardiovascular, liver, or gastrointestinal disorders may receive ½ tablet twice daily
Syrup
Children: recommended daily dose 12 mg/kg in two divided doses; if response is inadequate, dose may be increased up to 18 mg/kg under medical supervision
Adults: 2 measuring cups (20 ml = 400 mg) twice daily
Elderly: 1 measuring cup (10 ml = 200 mg) twice daily
Rare: nausea, vomiting, headache, irritability, insomnia, palpitations, tachycardia
Hypersensitivity to any component of the medication
Animal studies indicate doxofylline does not harm the fetus or reproductive function
Use during pregnancy only if clearly needed
No data available on use during breastfeeding
Half-life of doxofylline may be prolonged in severe liver or heart failure
Certain drugs may inhibit xanthine (including doxofylline) elimination, e.g., erythromycin, troleandomycin, lincomycin, allopurinol, cimetidine, propranolol, influenza vaccine – dose adjustment may be necessary
Phenytoin, other anticonvulsants, and smoking accelerate doxofylline elimination – dose increase may be required
Use with caution in patients with peptic ulcer or impaired liver function
Serious arrhythmias are not well-documented, but palpitations may appear as the first symptom
If side effects occur, discontinue therapy; resumption at reduced doses is possible only under medical supervision
Doxofylline should not be used with other xanthine derivatives (e.g., ephedrine) due to potential toxic synergism
Some drugs may slow doxofylline elimination, e.g., erythromycin, troleandomycin, lincomycin, allopurinol, cimetidine, ranitidine, propranolol, influenza vaccine
No dependence or adverse effects related to serum levels of doxofylline have been reported
